发给老马备查:2 j# k. ?0 R9 |
滴水察海(69304838) 15:23:23
v! N5 n& d' N9 p; V老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱+ j z' [, H: N( H) L/ c
吉非替尼和S-1连用的依据; f, T9 @) ~9 C3 w4 m4 k' _
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.5 o3 j7 V# L+ z }. V0 M
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达7 L7 m7 s) ~9 V# q0 G; T
这样是不是推理出,耐药后,可以用S-1和培美了?0 u+ q/ J# m t! t$ ^2 t- ]
结论:' {& ^4 B3 d/ p- c2 L6 z
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |