看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。
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; U0 x! }- E k9 }3 u! y: hCurrently available feasibility data for possible combination strategies.
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Combination Feasibility according to preliminary data
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8 B0 M! A/ S( FBevacizumab + sorafenib Yes, reduced dose
2 {' x1 Y( n9 U! [. q2 {% J, _: CBevacizumab + sunitinib† No 4 B3 v5 R V* M$ A, l& t
Bevacizumab + temsirolimus Yes
% {& K N$ @* k1 @5 XBevacizumab + everolimus Yes 8 u9 i8 V" O2 e# @8 f+ ]
Sorafenib + sunitinib ? 8 T- [* ?* {8 P7 o5 j. V- X; K! U
Sorafenib + temsirolimus Yes, reduced dose
4 Z8 }6 I& P! _% U- P2 RSorafenib + everolimus Yes, reduced dose 9 E R# d/ I5 B: [4 Y7 H1 G
Sunitinib + temsirolimus† No
% T# V1 d$ s6 f: c3 Y: F% GSunitinib + everolimus ?
4 [" h/ |4 W. E* B( MTemsirolimus + everolimus ?
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†Led to US FDA warning.4 @" [- j, B9 F- n( l1 D
?: As yet unattempted combination.
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